How cell death shapes cancer

Functional avidity-driven activation-induced cell death shapes CTL immunodominance.

Immunodominance is a complex phenomenon that relies on a mere numerical concept, while being potentially influenced at every step of the immune response. We investigated the mechanisms leading to the establishment of CTL immunodominance in a retroviral model and found that the previously defined subdominant Env-specific CD8(+) T cells are endowed with an unexpectedly higher functional avidity t...

How Experience Shapes Vision

Michael J. Tarr received his PhD from M.I.T. in 1989. He is currently the Fox Professor of Ophthalmology and Visual Sciences and a Professor of Cognitive and Linguistic Sciences at Brown University. He is the recipient of the 1997 APA Distinguished Scientific Award for Early Career Contribution to Psychology in the Area of Cognition/Human Learning and the 2003 Troland Research Award from the Na...

T Cells and Cancer: How Metabolism Shapes Immunity

Tumor microenvironment is characterized by a consistent reduction in oxygen and blood-borne nutrients that significantly affects the metabolism of distinct cell subsets. Immune cells populating malignant lesions need to activate alternative pathways to overcome tumor-prolonged nutrient deprivation. In particular, the metabolic switch occurring in transforming tissues dramatically impacts on tum...

How Similarity Shapes Diagrams

Most diagrams communicate effectively despite the fact that diagrams as a group have a minium of conventions and a high tolerance for novelty. This paper proposes that the diversity and felicity of diagrammatic representation is based on three kinds of similarity between semantic propositions and spatial representations that allow people to interpret diagrams consistently with a minimum of effo...

How Communication Shapes Culture